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About Hemophilia Bleeding Disorders Overview

A Quick Comparison Of Selected Bleeding Disorders

Factor Deficiencies

Disorder Estimated Rate of Occurrence Gender Affected Key Facts
Hemophilia A1 1 in 5,000 males Almost exclusively males
  • About 80 percent of people with hemophilia have hemophilia A, a deficiency of factor VIII
Hemophilia B2 1 in 25,000 males Almost exclusively males
  • About 20 percent have hemophilia B, a deficiency of factor IX
Factor I deficiency3 1-2 in 1,000,000 people Males and females equally
  • Also called fibrinogen deficiency
  • Impairs platelet function and clotting
Factor II deficiency4 1 in 2,000,000 people Males and females equally
  • Also called prothrombin deficiency
  • Can be congenital or acquired
Factor V deficiency5 1 in 1,000,000 people Males and females equally
  • Also called parahemophilia
  • Bleeding is usually mild
Factor VII deficiency6 1 in 500,000 people Males and females equally
  • Also called proconvertin deficiency or Alexander's disease
  • Bleeding can be severe
Factor X deficiency7 1 in 500,000 people Males and females equally
  • Also called Stuart-Prower factor deficiency
  • Bleeding can be mild to severe
Factor XI deficiency8
  • 1 in 100,000 people
  • Occurs much more frequently in some ethnic groups (Jews of eastern European ancestry)
 Males and females equally
  • Bleeding can be severe
  • Also known as hemophilia C
Factor XII deficiency9 1 in 1,000,000 Males and females equally
  • Bleeding symptoms are rare
  • Clots in the bloodstream often form
Factor XIII deficiency10 1 in 5,000,000 people Males and females equally
  • Clots form and break down repeatedly
  • Results in poor woundhealing and unusual scar formation

Platelet Disorders

Disorder Estimated Rate of Occurrence Gender Affected Key Facts
von Willebrand's disease (vWD)11 1 to 2 in 100 people Males and females equally
  • The most common inherited bleeding disorder

References

  1. Hemophilia A (factor VIII Deficiency). National Hemophilia Foundation website. http://www.hemophilia.org/NHFWeb/MainPgs/MainNHF.aspx?menuid=180&contentid=45&rptname=bleeding. Accessed June 8, 2011.
  2. Hemophilia B (factor IX). National Hemophilia Foundation website. http://www.hemophilia.org/NHFWeb/MainPgs/MainNHF.aspx?menuid=181&contentid=46&rptname=bleeding. Accessed June 8, 2011.
  3. Factor I Deficiency. National Hemophilia Foundation website. http://www.hemophilia.org/NHFWeb/MainPgs/MainNHF.aspx?menuid=184&contentid=44&rptname=bleeding. Accessed June 8, 2011.
  4. Factor II Deficiency. National Hemophilia Foundation website. http://www.hemophilia.org/NHFWeb/MainPgs/MainNHF.aspx?menuid=185&contentid=48&rptname=bleeding. Accessed June 8, 2011.
  5. Factor V Deficiency. National Hemophilia Foundation website. http://www.hemophilia.org/NHFWeb/MainPgs/MainNHF.aspx?menuid=186&contentid=409&rptname=bleeding. Accessed June 8, 2011.
  6. Factor VII Deficiency. National Hemophilia Foundation website. http://www.hemophilia.org/NHFWeb/MainPgs/MainNHF.aspx?menuid=187&contentid=50&rptname=bleeding. Accessed June 8, 2011.
  7. Factor X Deficiency. National Hemophilia Foundation website. http://www.hemophilia.org/NHFWeb/MainPgs/MainNHF.aspx?menuid=188&contentid=52&rptname=bleeding. Accessed June 8, 2011.
  8. Factor XI Deficiency. National Hemophilia Foundation website. http://www.hemophilia.org/NHFWeb/MainPgs/MainNHF.aspx?menuid=189&contentid=54&rptname=bleeding. Accessed June 8, 2011.
  9. Factor XII Deficiency. National Hemophilia Foundation website. http://www.hemophilia.org/NHFWeb/MainPgs/MainNHF.aspx?menuid=205&contentid=56&rptname=bleeding. Accessed June 8, 2011.
  10. Factor XIII Deficiency. National Hemophilia Foundation website. http://www.hemophilia.org/NHFWeb/MainPgs/MainNHF.aspx?menuid=190&contentid=58&rptname=bleeding. Accessed June 8, 2011.
  11. Von Willebrands Disease. National Hemophilia Foundation website. http://www.hemophilia.org/NHFWeb/MainPgs/MainNHF.aspx?menuid=182&contentid=47&rptname=bleeding. Accessed June 8, 2011.